Acute anemia accentuates cerebral injury following neurotrauma in rats
نویسندگان
چکیده
منابع مشابه
Severe hemodilutional anemia increases cerebral tissue injury following acute neurotrauma.
Anemia may worsen neurological outcomes following traumatic brain injury (TBI) by undefined mechanisms. We hypothesized that hemodilutional anemia accentuates hypoxic cerebral injury following TBI. Anesthetized rats underwent unilateral TBI or sham injury (n > or = 7). Target hemoglobin concentrations between 50 and 70 g/l were achieved by exchanging 40-50% of the blood volume (1:1) with pentas...
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introduction: in iran, thousands of young individuals become victims of head injury annually. head injury can damage neuronal cells which may in turn complicate the recovery of the patients. also, the increase of iron in cerebrospinal fluid (csf) following head injury may contribute to the hypoxic-ischemia brain damage by catalyzing the formation of free radicals (harber-weiss rection). the obj...
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OBJECTIVE To determine the role of asymmetric dimethylarginine (ADMA) in acute lung injury induced by cerebral ischemia/reperfusion (I/R) injury in rats. METHODS Adult male SD rats were randomly divided into 4 groups, namely the sham-operated group (S), cerebral I/R model group, ADMA+I/R group, and dimethylarginine dimethylaminohydrolase (DDAH)+I/R group. In the latter 3 groups, acute lung in...
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While a wide array of pathological changes occur in cerebral arteries following subarachnoid hemorrhage (SAH), the most consistent is endothelial damage. Since the endothelium normally modulates reflexes that influence vascular tone, any damage to it may represent a significant contributor to cerebral vasospasm following SAH. This experimental study investigates the correlation between end...
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ژورنال
عنوان ژورنال: Canadian Journal of Anesthesia/Journal canadien d'anesthésie
سال: 2007
ISSN: 0832-610X,1496-8975
DOI: 10.1007/bf03019995